Size and structure of microspheres have important effects on applications

and how to control size and structure precisely is a challenge to process engineering. A new process

membrane emulsification process

was developed to prepare uniform emulsion and microspheres

and the mechanism of the formation of uniform droplets was investigated. Uniform microspheres were successfully obtained from oil/water

water/oil

and water/oil/water emulsion systems. By developing quantitative analysis method for structure evolution

the pore size control became easier. In order to meet new requirement in biochemical engineering

new processes were developed to prepare gigaporous microspheres with pore size controllable between 100 nm and microns. By utilizing uniform size and different structure of microspheres

their effects on applications were studied. With microspheres used as separation media

uniform size improved the separation resolution of proteins

and gigaporous microsphere allowed super-macromolecules to diffuse into the inside of microsphere

resulting in higher purification recovery. The size showed apparent effect on microsphere distribution in gastrointestinal tract

and hollow-porous microsphere reduced blood glucose level significantly

with microspheres used as oral drug carrier.