Mixed solvent (water-ethanol) was screened out for cooling crystallization of fructose. The instrument

Crystalline was used to determine the solubility and metastable zone of fructose in the binary mixed solvent of water-ethanol (mole fraction of water 0.39). The experimental data of solubility were correlated as a function of temperature by using the Apelblat equation. Based on thermodynamic data of fructose crystallization

the cooling crystallization process was designed and optimized

with over 78.2% yield much higher than that by cooling crystallization in aqueous solution and purity higher than 99%. Compared with the commercially available crystalline fructose

the product crystals were of regular shape

high toughness and narrow crystal size distribution. Laser particle size analyzer

Malvern 3000 was used to determine the continuous crystallization kinetics of fructose

and the crystallization kinetics equation was built by the model of population balance equation proposed by Larson and Randolph and was of size-independent growth with particle size larger than 100μm. The exponent of growth rate was bigger than that of nucleation rate and the crystals tended to grow rather than to nucleate in this size range.