玉米醇溶蛋白用作药物输送系统载体的研究进展

刘贵金; 汪红娣; 江燕斌

doi:10.3969/j.issn.0438-1157.2013.10.002

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玉米醇溶蛋白用作药物输送系统载体的研究进展

综述与专论 | 更新时间：2025-12-10

- 玉米醇溶蛋白用作药物输送系统载体的研究进展
- Research progress of Zein as carrier for drug delivery systems
- 化工学报 2013年第10期页码：3493-3504
- 作者机构：
  
  华南理工大学化学与化工学院,广东,广州,510640
- 作者简介：
  
  刘贵金(1989-),男,博士研究生.
- 基金信息：
- DOI：10.3969/j.issn.0438-1157.2013.10.002
  中图分类号： Q469
- 网络首发：2013-10-05，
  
  纸质出版：2013-10-05
- 稿件说明：
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刘贵金, 汪红娣, 江燕斌. 玉米醇溶蛋白用作药物输送系统载体的研究进展[J]. 化工学报, 2013,(10):3493-3504.

LIU Guijin, WANG Hongdi, JIANG Yanbin. Research progress of Zein as carrier for drug delivery systems[J]. CIESC Journal, 2013, (10): 3493-3504.
刘贵金, 汪红娣, 江燕斌. 玉米醇溶蛋白用作药物输送系统载体的研究进展[J]. 化工学报, 2013,(10):3493-3504. DOI： 10.3969/j.issn.0438-1157.2013.10.002.

LIU Guijin, WANG Hongdi, JIANG Yanbin. Research progress of Zein as carrier for drug delivery systems[J]. CIESC Journal, 2013, (10): 3493-3504. DOI： 10.3969/j.issn.0438-1157.2013.10.002.

摘要

玉米醇溶蛋白(Zein)是一种天然可食性植物大分子

具有可再生性、无毒性、两亲性及良好的生物相容性和生物可降解性

可通过自组装形成微球或纳米粒。近年来

Zein用作药物输送系统(drug delivery system

DDS)载体材料成为研究热点

可通过Zein的自组装特性将药物包载在其内部获得Zein-DDS微粒。本文简述了Zein的特性及其作为DDS载体的优势

总结了Zein-DDS的制备方法、性能及Zein的修饰改性研究进展

指出Zein具有较强的疏水性和抗胃酸分解特性

Zein-DDS可有效地提高药物稳定性、延缓药物释放及增强药物靶向性。因此

Zein用作DDS的载体具有广阔的应用前景

今后的研究工作将会在拓宽研究领域、改进制备方法及Zein的修饰改性等方面展开。

Abstract

Zein

one of the natural and edible biomacromolecules in plant

is renewable

nontoxic

biocompatible and biodegradable.Zein is capable of self-assembly into microspheres or nanoparticles because of its amphipathicity

and is an attractive drug carrier and has a promising prospect for drug delivery systems(DDS).Recently

the study of using Zein as carrier for drug delivery systems has become popular.The properties and advantages of Zein used as DDS carriers were introduced at first in this paper.Then

methods for the preparation of Zein-DDS and the characteristics of Zein-DDS were reviewed in detail.Moreover

the researches on the modification of Zein for carrier were also presented.In summary

Zein has a strong hydrophobicity and a good resistance to the digestive processes of stomach. Therefore

Zein-DDS can improve the stability of drugs

control and prolong drug release

and enhance drug targeting effectively.The future orientations could focus on broadening research fields

improving preparation methods and developing modification of Zein.

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