The drug polymorphism has a profound effect on the quality

safety and efficiency of the drug product.The Twelfth Five-Year Development Plan of China's Pharmaceutical Industry puts forward one of the major development tasks and technologies focused on the improvement in drug polymorphism study to enhance the quality and safety of the drugs.In this paper

the solubility behavior coupled with the solid state and solution mediated transformation of drug polymorphs are introduced and analyzed.In addition

solvent and additive/template play a critical role in the manipulation of drug crystal form.In many cases

physical field (ultrasound

microwave and high gravity-field)-assisted crystallization gives different results for the manipulation of drug crystal form by specific mechanism.Meanwhile

with the rapid development of process analytical technologies

process optimization and control are enhanced through getting more knowledge of drug polymorphism transformation.In the future

the research of transformation and manipulation of pharmaceutical drug polymorphism will focus on the molecular assembly and regulation

process analysis and structure-activity relationship of drugs.