Co-Cu bimetallic catalysts were prepared by equal volume impregnation.The effect of supports on Co-Cu bimetallic catalyst performance was investigated for direct synthesis of the performance of C2+ oxygenates from CH4 and CO by a step-wise reaction technology.Those catalysts were characterized by XRD，NH3-TPD and H2-TPR.The results show that supports have a greater impact on catalytic performance，the activity order of catalysts loaded on different supports for step-wise conversion of CH4 and syngas is Co-Cu/TiO2＞Co-Cu/Al2O3＞Co-Cu/SiO2 and the highest selectivity of C2+oxygenates is 79.9%.It is concluded that there is the interaction between the TiO2 and the active metal Co-Cu and the good dispersion of Co-Cu/TiO2 in the catalyst with high activity.In addition，the amount of surface acidity and moderate acid strength also favor the reaction.