According to principles and features of biological circulatory system，a novel monolithic catalyst chip with bionic micro-channel network configuration was proposed.It included a multi-stage and multi-function network with separated inflow and outflow systems.A series of high-resolution CFD simulations and optimizations were performed to investigate the characteristics of the bionic configuration.Compared with conventional fixed-bed catalyst chip，flow resistance was greatly reduced by using bionic micro-channel network at the same residence time.Back-mixing was lowered in the optimal bionic network. Strong robustness was verified for the bionic micro-channel network configuration，which would reduce worse effects induced by uncertain factors，such as short passing or blocking in micro-channel network. This kind of bionic network is an ideal configuration fit for monolithic catalyst chip.