Balaban R S , Nemoto S , Finkel T . Mitochondria, oxidants, and aging [J ] . Cell , 2005 , 120 ( 4 ): 483 - 495 .

Vakifahmetoglu-Norberg H , Ouchida A T , Norberg E . The role of mitochondria in metabolism and cell death [J ] . Biochemical and Biophysical Research Communications , 2017 , 482 ( 3 ): 426 - 431 .

Yousif L F , Stewart K M , Kelley S O . Targeting mitochondria with organelle-specific compounds: strategies and applications [J ] . ChemBiochem , 2009 , 10 ( 12 ): 1939 - 1950 .

Wu P , Zhao T , Wang S L , et al . Semicondutor quantum dots-based metal ion probes [J ] . Nanoscale , 2014 , 6 ( 1 ): 43 - 64 .

Lee M H , Kim J S , Sessler J L . Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules [J ] . Chemical Society Reviews , 2015 , 44 ( 13 ): 4185 - 4191 .

Vyas S , Zaganjor E , Haigis M C . Mitochondria and cancer [J ] . Cell , 2016 , 166 ( 3 ): 555 - 566 .

Zhao L M , Liu G , Zhang B F . A colorimetric and fluorescence enhancement anion probe based on coumarin compounds [J ] . Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2016 , 169 : 45 - 49 .

Lim C S , Cho B R . Two-photon probes for biomedical applications [J ] . BMB Reports , 2013 , 46 ( 4 ): 188 - 194 .

Zhang P S , Wang H , Zhang D , et al . Two-photon fluorescent probe for lysosome-targetable hypochlorous acid detection within living cells [J ] . Sensors and Actuators B: Chemical , 2018 , 255 : 2223 - 2231 .

姜娜 , 樊江莉 , 杨洪宝 , 等 . 线粒体荧光探针最新研究进展 [J ] . 化工学报 , 2016 , 67 ( 1 ): 176 - 190 .

Jiang N , Fan J L , Yang H B , et al . Progress in research of mitochondrial fluorescence probes [J ] . CIESC Journal , 2016 , 67 ( 1 ): 176 - 190 .

肖瑜峰 , 陈林海 , 吕伟 , 等 . 线粒体靶向的活性氧荧光探针的研究进展 [J ] . 生命的化学 , 2016 , 36 ( 4 ): 538 - 547 .

Xiao Y F , Chen L H , Lv W , et al . Mitochondrial targeting fluorescent probes for reactive oxygen species [J ] . Chemistry of Life , 2016 , 36 ( 4 ): 538 - 547 .

Frederickson C J , Koh J Y , Bush A I . The neurobiology of zinc in health and disease [J ] . Nature Reviews Neuroscience , 2005 , 6 ( 6 ): 449 - 462 .

Toshiyuki F , Yamasaki S , Nishida K , et al . Zinc homeostasis and signaling in health and diseases [J ] . Journal of Biological Inorganic Chemistry , 2011 , 16 ( 7 ): 1123 - 1134 .

Krężel A , Maret W . The biological inorganic chemistry of zinc ions [J ] . Archives of Biochemistry and Biophysics , 2016 , 611 : 3 - 19 .

刘璐璐 , 但飞君 , 付林娜 , 等 . 基于喹啉Zn 2+ 荧光探针的合成及其性能 [J ] . 精细化工 , 2017 , 34 ( 5 ): 481 - 487 .

Liu L L , Dan F J , Fu L N , et al . Synthesis and properties of a fluorescent probe for Zn 2+ based on quinoline [J ] . Fine Chemicals , 2017 , 34 ( 5 ): 481 - 487 .

Li J , Chen Y H , Chen T T , et al . A benzothiazole-based fluorescent probe for efficient detection and discrimination of Zn 2+ and Cd 2+ , using cysteine as an auxiliary reagent [J ] . Sensors and Actuators B: Chemical , 2018 , 268 : 446 - 455 .

Sreenath K , Allen J R , Davidson M W , et al . A FRET-based indicator for imaging mitochondrial zinc ions [J ] . Chemical Communications , 2011 , 47 ( 42 ): 11730 - 11732 .

Xue L , Li G P , Yu C L , et al . A ratiometric and targetable fluorescent sensor for quantification of mitochondrial zinc ions [J ] . Chemistry-A European Journal , 2012 , 18 ( 4 ): 1050 - 1054 .

Baek N Y , Heo C H , Lim C S , et al . A highly sensitive two-photon fluorescent probe for mitochondrial zinc ions in living tissue [J ] . Chemical Communications , 2012 , 48 ( 38 ): 4546 - 4548 .

Rathore K , Lim C S , Lee Y , et al . Dual-color imaging of cytosolic and mitochondrial zinc ions in live tissues with two-photon fluorescent probes [J ] . Organic & Biomolecular Chemistry , 2014 , 12 ( 21 ): 3406 - 3412 .

Ning P , Jiang J C , Li L C , et al . A mitochondria-targeted ratiometric two-photon fluorescent probe for biological zinc ions detection [J ] . Biosensors and Bioelectronics , 2016 , 77 : 921 - 927 .

Dalapati S , Jana S , Alam A , et al . Multifunctional fluorescent probe selective for Cu(II) and Fe(III) with dual-mode of binding approach [J ] . Sensors and Actuators B: Chemical , 2011 , 160 ( 1 ): 1106 - 1111 .

Su H T , Sun B , Chen L J , et al . Colorimetric sensing of dopamine based on the aggregation of gold nanoparticles induced by copper ions [J ] . Analytical Methods , 2012 , 4 ( 12 ): 3981 - 3986 .

Giuffrida M L , Rizzarelli E , Tomaselli G A , et al . A novel fully water-soluble Cu(I) probe for fluorescence live cell imaging [J ] . Chemical Communications , 2014 , 50 ( 69 ): 9835 - 9838 .

Hu L , Wang H , Fang B , et al . A reversible two-photon fluorescence probe for Cu(II) based on Schiff-base in HEPES buffer and in vivo imaging [J ] . Sensors and Actuators B: Chemical , 2017 , 251 : 993 - 1000 .

Dodani S C , Leary S C , Cobine P A , et al . A targetable fluorescent sensor reveals that copper-deficient SCO1 and SCO2 patient cells prioritize mitochondrial copper homeostasis [J ] . Journal of the American Chemical Society , 2011 , 133 ( 22 ): 8606 - 8616 .

Taki M , Akaoka K , Mitsui K , et al . A mitochondria-targeted turn-on fluorescent probe based on a rhodol platform for the detection of copper(I) [J ] . Organic & Biomolecular Chemistry , 2014 , 12 ( 27 ): 4999 - 5005 .

Shen C , Kolanowski J L , Tran C M N , et al . A ratiometric fluorescent sensor for the mitochondrial copper pool [J ] . Metallomics , 2016 , 8 ( 9 ): 915 - 919 .

Li H , Zhang R L , Li C X , et al . Real-time detection and imaging of copper(Ⅱ) in cellular mitochondria [J ] . Organic & Biomolecular Chemistry , 2017 , 15 ( 3 ): 598 - 604 .

Renzoni A , Zino F , Franchi E . Mercury levels along the food chain and risk for exposed populations [J ] . Environmental Research , 1998 , 77 ( 2 ): 68 - 72 .

Richardson S D , Ternes T A . Water analysis: emerging contaminants and current issues [J ] . Analytical Chemistry , 2005 , 77 ( 12 ): 3807 - 3838 .

Gao Y Y , Ma T T , Ou Z Z , et al . Highly sensitive and selective turn-on fluorescent chemosensors for Hg 2+ based on thioacetal modified pyrene [J ] . Talanta , 2018 , 178 : 663 - 669 .

Deepa S , Rajendrakumar R . A symmetrical luminol based azo derivative for trimodal ratiometric Hg 2+ sensing and its application to bioimaging in living cells [J ] . Journal of Photochemistry and Photobiology A: Chemistry , 2018 , 364 : 773 - 786 .

Chen J H , Liu W M , Zhou B J , et al . Coumarin- and rhodamine-fused deep red fluorescent dyes: synthesis, photophysical properties, and bioimaging in vitro [J ] . The Journal of Organic Chemistry , 2013 , 78 ( 12 ): 6121 - 6130 .

Agarwalla H , Mahajan P S , Sahu D , et al . A switch-on NIR probe for specific detection of Hg 2+ ion in aqueous medium and in mitochondria [J ] . Inorganic Chemistry , 2016 , 55 ( 22 ): 12052 - 12060 .

Long L , Tan X , Luo S L , et al . Fluorinated near-infrared fluorescent probes for specific detection of Hg 2+ in an aqueous medium and mitochondria of living cells [J ] . New Journal of Chemistry , 2017 , 41 ( 17 ): 8899 - 8904 .

Kakhlon O , Cabantchik Z I . The labile iron pool: characterization, measurement, and participation in cellular processes [J ] . Free Radical Biology and Medicine , 2002 , 33 ( 8 ): 1037 - 1046 .

Swaminathan S , Fonseca V A , Alam M G , et al . The role of iron in diabetes and its complications [J ] . Diabetes Care , 2007 , 30 ( 7 ): 1926 - 1933 .

Chen X , Sun W , Bai Y J , et al . Novel rhodamine Schiff base type naked-eye fluorescent probe for sensing Fe 3+ and the application in cell [J ] . Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2018 , 191 : 566 - 572 .

Chen W D , Gong W T , Ye Z Q , et al . FRET-based ratiometric fluorescent probes for selective Fe 3+ sensing and their applications in mitochondria [J ] . Dalton Transactions , 2013 , 42 ( 28 ): 10093 - 10096 .

Zhu C C , Wang M J , Qiu L , et al . A mitochondria-targeting fluorescent Fe 3+ probe and its application in labile Fe 3+ monitoring via imaging and flow cytometry [J ] . Dyes and Pigments , 2018 , 157 : 328 - 333 .

Block W D , Knapp E L . Metabolism, toxicity, and manner of action of gold compounds in the treatment of arthritis [J ] . The Journal of Pharmacology and Experimental Therapeutics , 1945 , 83 ( 4 ): 275 - 278 .

Wang Y , Liu Y W , Miao J F , et al . A novel Bodipy-based fluorescent probe for Au 3+ ions with high selectivity and its application to bioimaging [J ] . Sensors and Actuators B: Chemical , 2016 , 226 : 364 - 369 .

Srisuratsiri P , Kanjanasirirat P , Chairongdua A , et al . Reversible rhodamine-alkyne Au 3+ -selective chemosensor and its bioimaging application [J ] . Tetrahedron Letters , 2017 , 58 ( 32 ): 3194 - 3199 .

Feng Y , Li D X , Wang Q , et al . A carbazole-based mitochondria-targeted two-photon fluorescent probe for gold ions and its application in living cell imaging [J ] . Sensors and Actuators B: Chemical , 2016 , 225 : 572 - 578 .

Wang W J , Zhang W , Feng Y , et al . Strategically modified highly selective mitochondria-targeted two-photon fluorescent probe for Au 3+ employing Schiff-base: inhibited C=N isomerization vs . hydrolysis mechanism [J ] . Dyes and Pigments , 2018 , 150 : 241 - 251 .

Wolf F I , Torsello A , Fasanella S , et al . Cell physiology of magnesium [J ] . Molecular Aspects of Medicine , 2003 , 24 ( 1 / 2 / 3 ): 11 - 26 .

Marimuthu P , Ramu A . A ratiometric fluorescence chemosensor for Mg 2+ ion and its live cell imaging [J ] . Sensors and Actuators B: Chemical , 2018 , 266 : 384 - 391 .

Liu M , Yu X , Li M , et al . Fluorescent probes for the detection of magnesium ions (Mg 2+ ): from design to application [J ] . RSC Advances , 2018 , 8 ( 23 ): 12573 - 12587 .

Shindo Y , Fujii T , Komatsu H , et al . Newly developed Mg 2+ -selective fluorescent probe enables visualization of Mg 2+ dynamics in mitochondria [J ] . PLoS One , 2011 , 6 ( 8 ): e23684 .

Zhang G , Gruskos J J , Afzal M S , et al . Visualizing changes in mitochondrial Mg 2+ during apoptosis with organelle-targeted triazole-based ratiometric fluorescent sensors [J ] . Chemical Science , 2015 , 6 ( 12 ): 6841 - 6846 .

Wang Z W , Saifee O , Nonet M L , et al . SLO-1 potassium channels control quantal content of neurotransmitter release at the C. elegans neuromuscular junction [J ] . Neuron , 2001 , 32 ( 5 ): 867 - 881 .

Xiong M Y , Zhu H J , Rong Q M , et al . A membrane-anchore d fluorescent probe for detecting K + in the cell microenvironment [J ] . Chemical Communications , 2016 , 52 ( 25 ): 4679 - 4682 .

Schwarze T , Riemer J , Holdt H J . A ratiometric fluorescent probe for K + in water based on a phenylaza-18-crown-6 lariat ether [J ] . Chemistry-A European Journal , 2018 , 24 ( 40 ): 10116 - 10121 .

Kong X X , Su F Y , Zhang L Q , et al . A highly selective mitochondria-targeting fluorescent K + sensor [J ] . Angewandte Chemie International Edition , 2015 , 54 ( 41 ): 12053 - 12056 .

Schindler M , Grabski S , Hoff E , et al . Defective pH regulation of acidic compartments in human breast cancer cells (MCF-7) is normalized in adriamycin-resistant cells (MCF-7adr) [J ] . Biochemistry , 1996 , 35 ( 9 ): 2811 - 2817 .

Holopainen J M , Saarikoski J , Kinnunen P K J , et al . Elevated lysosomal pH in neuronal ceroid lipofuscinoses (NCLs) [J ] . European Journal of Biochemistry , 2001 , 268 ( 22 ): 5851 - 5856 .

Zhu Q , Li Z , Mu L , et al . A quinoline-based fluorometric and colorimetric dual-modal pH probe and its application in bioimaging [J ] . Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2018 , 188 : 230 - 236 .

Lee D , Swamy K M K , Hong J , et al . A rhodamine-based fluorescent probe for the detection of lysosomal pH changes in living cells [J ] . Sensors and Actuators B: Chemical , 2018 , 266 : 416 - 421 .

Li P , Xiao H B , Cheng Y F , et al . A near-infrared-emitting fluorescent probe for monitoring mitochondrial pH [J ] . Chemical Communications , 2014 , 50 ( 54 ): 7184 - 7187 .

Chen Y C , Zhu C C , Cen J J , et al . Ratiometric detection of pH fluctuation in mitochondria with a new fluorescein/cyanine hybrid sensor [J ] . Chemical Science , 2015 , 6 ( 5 ): 3187 - 3194 .

Wu Y M , Li K , Liu Y H , et al . Mitochondria-targeted ratiometric fluorescent probe for real time monitoring of pH in living cells [J ] . Biomaterials , 2015 , 53 : 669 - 678 .

Sarkar A R , Heo C H , Xu L , et al . A ratiometric two-photon probe for quantitative imaging of mitochondrial pH values [J ] . Chemical Science , 2016 , 7 ( 1 ): 766 - 773 .

Xiong X Z , Liu J L , He W H , et al . Dose-effect relationship between drinking water fluoride levels and damage to liver and kidney functions in children [J ] . Environmental Research , 2007 , 103 ( 1 ): 112 - 116 .

张世玲 , 彭孝军 . 氟离子荧光探针的研究进展 [J ] . 化工学报 , 2016 , 67 ( 1 ): 191 - 201 .

Zhang S L , Peng X J . Research progress on fluorescent probes for fluoride ions [J ] . CIESC Journal , 2016 , 67 ( 1 ): 191 - 201 .

Yuan X , Zhao C X , Lu Y X , et al . A novel naphthalimide-based probe for highly sensitive and selective recognition of fluoride ion [J ] . Journal of Photochemistry and Photobiology A: Chemistry , 2018 , 361 : 41 - 47 .

Du M , Huo B L , Liu J M , et al . A near-infrared fluorescent probe for selective and quantitative detection of fluoride ions based on Si-Rhodamine [J ] . Analytica Chimica Acta , 2018 , 1030 : 172 - 182 .

Zhang S L , Fan J L , Zhang S Z , et al . Lighting up fluoride ions in cellular mitochondria using a highly selective and sensitive fluorescent probe [J ] . Chemical Communications , 2014 , 50 ( 90 ): 14021 - 14024 .

Wu Z S , Tang X J . Visualizing fluoride ion in mitochondria and lysosome of living cells and in living mice with positively charged ratiometric probes [J ] . Analytical Chemistry , 2015 , 87 ( 17 ): 8613 - 8617 .

Shen Y M , Zhang X Y , Zhang Y Y , et al . An ICT-modulated strategy to construct colorimetric and ratiometric fluorescent sensor for mitochondria-targeted fluoride ion in cell living [J ] . Sensors and Actuators B: Chemical , 2018 , 258 : 544 - 549 .

Zhou K , Ren M G , Wang L , et al . A targetable fluorescent probe for real-time monitoring of fluoride ions in mitochondria [J ] . Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2018 , 204 : 777 - 782 .

Pacher P , Beckman J S , Liaudet L . Nitric oxide and peroxynitrite in health and disease [J ] . Physiological Reviews , 2007 , 87 ( 1 ): 315 - 424 .

Li H Y , Li X H , Wu X F , et al . Observation of the generation of ONOO – in mitochondria under various stimuli with a sensitive fluorescence probe [J ] . Analytical Chemistry , 2017 , 89 ( 10 ): 5519 - 5525 .

Zhu B C , Wang Z K , Zhao Z Y , et al . A simple highly selective and sensitive hydroquinone-based two-photon fluorescent probe for imaging peroxynitrite in live cells [J ] . Sensors and Actuators B: Chemical , 2018 , 262 : 380 - 385 .

Zhang H X , Liu J , Sun Y Q , et al . A mitochondria-targetable fluorescent probe for peroxynitrite: fast response and high selectivity [J ] . Chemical Communications , 2015 , 51 ( 13 ): 2721 - 2724 .

Zhu B C , Zhang M , Wu L , et al . A highly specific far-red fluorescent probe for imaging endogenous peroxynitrite in the mitochondria of living cells [J ] . Sensors and Actuators B: Chemical , 2018 , 257 : 436 - 441 .

Cheng D , Pan Y , Wang L , et al . Selective visualization of the endogenous peroxynitrite in an inflamed mouse model by a mitochondria-targetable two-photon ratiometric fluorescent probe [J ] . Journal of the American Chemical Society , 2017 , 139 ( 1 ): 285 - 292 .

Sun W , Shi Y D , Ding A X , et al . Imaging viscosity and peroxynitrite by a mitochondria-targeting two-photon ratiometric fluorescent probe [J ] . Sensors and Actuators B: Chemical , 2018 , 276 : 238 - 246 .

McCord J M . Free radicals and inflammation: protection of synovial fluid by superoxide dismutase [J ] . Science , 1974 , 185 ( 4150 ): 529 - 531 .

Lu D Q , Zhou L Y , Wang R W , et al . A two-photon fluorescent probe for endogenous superoxide anion radical detection and imaging in living cells and tissues [J ] . Sensors and Actuators B: Chemical , 2017 , 250 : 259 - 266 .

Li R Q , Mao Z Q , Rong L , et al . A two-photon fluorescent probe for exogenous and endogenous superoxide anion imaging in vitro and in vivo [J ] . Biosensors and Bioelectronics , 2017 , 87 : 73 - 80 .

Zhang Z , Fan J L , Zhao Y H , et al . Mitochondria-accessing ratiometric fluorescent probe for imaging endogenous superoxide anion in live cells and daphnia magna [J ] . ACS Sensors , 2018 , 3 ( 3 ): 735 - 741 .

Han X Y , Wang R , Song X Y , et al . A mitochondrial-targeting near-infrared fluorescent probe for bioimaging and evaluating endogenous superoxide anion changes during ischemia/reperfusion injury [J ] . Biomaterials , 2018 , 156 : 134 - 146 .

Li P , Zhang W , Li K X , et al . Mitochondria-targeted reaction-based two-photon fluorescent probe for imaging of superoxide anion in live cells and in vivo [J ] . Analytical Chemistry , 2013 , 85 ( 20 ): 9877 - 9881 .

Qin G H , Wu M Q , Wang J X , et al . Sulfur dioxide contributes to the cardiac and mitochondrial dysfunction in rats [J ] . Toxicological Sciences , 2016 , 151 ( 2 ): 334 - 346 .

Ye Z , Duan C , Sheng R L , et al . A novel colorimetric and ratiometric fluorescent probe for visualizing SO 2 derivatives in environment and living cells [J ] . Talanta , 2018 , 176 : 389 - 396 .

Huang M F , Chen L N , Ning J Y , et al . A new lipid droplets-targeted fluorescence probe for specific detection of SO 2 derivatives in living cells [J ] . Sensors and Actuators B: Chemical , 2018 , 261 : 196 - 202 .

Yin G X , Gan Y B , Yu T , et al . A dual-emission and mitochondria-targeted fluorescent probe for rapid detection of SO 2 derivatives and its imaging in living cells [J ] . Talanta , 2019 , 191 : 428 - 434 .

Li H D , Zhou X , Fan J L , et al . Fluorescence imaging of SO 2 derivatives in Daphnia magna with a mitochondria-targeted two-photon ratiometric fluorescent probe [J ] . Sensors and Actuators B: Chemical , 2018 , 254 : 709 - 718 .

Zhao M , Liu D K , Zhou L , et al . Two water-soluble two-photon fluorescence probes for ratiometric imaging endogenous SO 2 derivatives in mitochondria [J ] . Sensors and Actuators B: Chemical , 2018 , 255 : 1228 - 1237 .