2,4-D/CMC接枝物纳米粒子的制备与缓释性能研究

邱松发; 许斌华; 林冠权; 周新华; 陈铧耀; 周红军

doi:10.11949/j.issn.0438-1157.20181292

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2,4-D/CMC接枝物纳米粒子的制备与缓释性能研究

材料化学工程与纳米技术 | 更新时间：2026-07-24

- 2,4-D/CMC接枝物纳米粒子的制备与缓释性能研究
- Preparation and sustained release performance of 2,4-D/grafted CMC nanoparticles
- 化工学报 2019年70卷第5期页码：143016160-143016168
- 作者机构：
  
  仲恺农业工程学院化学化工学院，广东省普通高校农用绿色精细化学品重点实验室，广东广州 510225
- 作者简介：
  
  邱松发（1994—），男，硕士研究生，501946228@qq.com
  周红军（1975—），男，教授，hongjunzhou@163.com
- 基金信息：
  
  国家自然科学基金项目(21576303);广东省自然科学基金项目(2016A030313375, 2017A030311003);广州市科技计划项目(201604020054)
- DOI：10.11949/j.issn.0438-1157.20181292
  中图分类号： TQ 450.6
- 收稿：2018-11-02，
  
  修回：2019-01-29，
  
  网络首发：2026-07-24，
  
  纸质出版：2019-05-05
- 稿件说明：
移动端阅览
邱松发, 许斌华, 林冠权, 周新华, 陈铧耀, 周红军. 2,4-D/CMC接枝物纳米粒子的制备与缓释性能研究[J]. 化工学报, 2019, 70(5): 2007-2015

QIU Songfa, XU Binhua, LIN Guanquan, ZHOU Xinhua, CHEN Huayao, ZHOU Hongjun. Preparation and sustained release performance of 2,4-D/grafted CMC nanoparticles[J]. CIESC Journal, 2019, 70(5): 2007-2015
邱松发, 许斌华, 林冠权, 周新华, 陈铧耀, 周红军. 2,4-D/CMC接枝物纳米粒子的制备与缓释性能研究[J]. 化工学报, 2019, 70(5): 2007-2015 DOI： 10.11949/j.issn.0438-1157.20181292.

QIU Songfa, XU Binhua, LIN Guanquan, ZHOU Xinhua, CHEN Huayao, ZHOU Hongjun. Preparation and sustained release performance of 2,4-D/grafted CMC nanoparticles[J]. CIESC Journal, 2019, 70(5): 2007-2015 DOI： 10.11949/j.issn.0438-1157.20181292.

摘要

以羧甲基纤维素钠（CMC）为基材，甲基丙烯酸甲酯（MMA）和二甲基二烯丙基氯化铵（DMDAAC）为改性单体，通过乳液聚合制备了CMC-

-P(MMA-DMDAAC)共聚物，采用自组装方法负载2

4-二氯苯氧乙酸（2

4-D）得到2

4-D/CMC-

-P(MMA-DMDAAC)纳米药物缓释体系。利用傅里叶红外光谱（FTIR）、差示扫描量热法（DSC）、热重分析（TGA）、扫描电镜（SEM）、粒度分析仪对其结构和形貌进行表征，并探究其载药性能和缓释性能。结果表明，2

4-D/CMC-

-P(MMA-DMDAAC)载药粒子呈笼状结构，粒度分布为160～425 nm；其载药率随着CMC∶MMA∶DMDAAC的摩尔比增大而提高，最高可达40.8%；其药物累计释放率随CMC∶MMA∶DMDAAC的摩尔比增大而降低，其释放行为符合Weibull模型，遵循Fick扩散机理。

Abstract

CMC-

-P(MMA-DMDAAC) was prepared by emulsion copolymerization and trapping as well as encapsulation of 2

-D

via

self-assembly resulted in the formation of 2

4-D/CMC-

-PDMDAAC nanoparticles. Its structure and morphology were characterized by Fourier transform infrared spectroscopy (FTIR)

differential scanning calorimetry (DSC)

thermogravimetric analysis (TGA)

scanning electron (SEM) and dynamic light scattering (DLS). Furthermore

the encapsulation efficiency and sustained-release characteristics were investigated. The results demonstrated that the 2

4-D/CMC-

-P(MMA-DMDAAC) drug-loaded particles showed a cage structure with a particle size distribution from 160 nm to 425 nm. Moreover

the encapsulation efficiency increased as the molar ratio of monomers increased

which could reach up to 40.8%. In addition

the higher molar ratio of the monomers was

the lower cumulative release rate of the drug exhibited. Overall

the mechanism of release of 2

4-D from nanocarriers was consistent with Fickian behavior.

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