Industrial crystallization is a “semi-artistic science” and its process has the characteristics of multi-objective

non-linear and strong coupling. It is well-known by international scholars as one of the most difficult unit operations of chemical engineering to design. On the basis of the domestic and international research progresses on the topic of industrial crystallization and intelligent manufacturing

this review intends to construct a multi-scale research framework of industrial crystallization with intelligent manufacturing technologies to confront with the major strategic demands and historical opportunities of intelligent manufacturing development. The review summarizes the application of core intelligent manufacturing technologies including AI

cloud computing

and internet of things in industrial crystallization with some relevant cases. It will mainly focus on the analysis and discussion of development status and potential integration point of prediction of solubility

polymorphs

crystal habit

and co-crystals with intelligent manufacturing. Some methods for predicting the crystallization conditions of proteins is introduced. Finally

the intelligent control technologies of perception

analysis and decision in crystallization process were reviewed.