甲醇-水溶剂中L<italic style="font-style: italic">-</italic>苯丙氨酸结晶热力学

曹小雪; 吉绍长; 匡雯婕; 廖安平; 蓝平; 张金彦

doi:10.11949/j.issn.0438-1157.20180893

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甲醇-水溶剂中L-苯丙氨酸结晶热力学

热力学 | 更新时间：2026-07-24

- 甲醇-水溶剂中L-苯丙氨酸结晶热力学
- Crystallization thermodynamics of L-phenylalanine in methanol-water solvent
- 化工学报 2019年70卷第4期页码：1255-1262
- 作者机构：
  
  1.广西民族大学化学化工学院，广西多糖材料与改性重点实验室，广西高校化学与生物转化过程新技术重点实验室，广西南宁 530006
  2.广西烟草专卖局，广西南宁 530006
- 作者简介：
  
  曹小雪（1992—），女，硕士，cxx818221@163.com
  张金彦（1984—），女，博士，副教授，zjy_03@126.com
- 基金信息：
  
  国家自然科学基金项目(21606056);广西自然科学基金项目(2017GXNSFAA198091;2014GXNSFBA118037);广西生物多糖分离纯化及改性研究平台建设项目(桂科ZY18076005);广西民族大学相思湖创新团队项目(2016);广西民族大学研究生教育创新计划项目(gxun-chxzs2017128)
- DOI：10.11949/j.issn.0438-1157.20180893
  中图分类号： TQ 026.5
- 收稿：2018-08-03，
  
  修回：2018-11-01，
  
  网络首发：2020-06-15，
  
  纸质出版：2019-04-12
- 稿件说明：
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曹小雪, 吉绍长, 匡雯婕, 廖安平, 蓝平, 张金彦. 甲醇-水溶剂中L-苯丙氨酸结晶热力学[J]. 化工学报, 2019, 70(4): 1255-1262

CAO Xiaoxue, JI Shaochang, KUANG Wenjie, LIAO Anping, LAN Ping, ZHANG Jinyan. Crystallization thermodynamics of L-phenylalanine in methanol-water solvent[J]. CIESC Journal, 2019, 70(4): 1255-1262
曹小雪, 吉绍长, 匡雯婕, 廖安平, 蓝平, 张金彦. 甲醇-水溶剂中L-苯丙氨酸结晶热力学[J]. 化工学报, 2019, 70(4): 1255-1262 DOI： 10.11949/j.issn.0438-1157.20180893.

CAO Xiaoxue, JI Shaochang, KUANG Wenjie, LIAO Anping, LAN Ping, ZHANG Jinyan. Crystallization thermodynamics of L-phenylalanine in methanol-water solvent[J]. CIESC Journal, 2019, 70(4): 1255-1262 DOI： 10.11949/j.issn.0438-1157.20180893.

摘要

在293.15~322.15 K温度范围内，研究L

苯丙氨酸无水物在甲醇-水混合溶剂中溶解度和超溶解度特性，得到L

苯丙氨酸无水物结晶介稳区，计算了成核级数及成核速率，考察了不同初始温度和降温速率对介稳区宽度的影响，并通过研究L

苯丙氨酸297.15 K和302.15 K的转晶水活度，依据溶解度特性绘制L

苯丙氨酸-甲醇-水在该温度下的三元相图。溶解度数据用Apelblat方程、

λh

方程关联、van t Hoff方程拟合。结果表明，L

苯丙氨酸无水物溶解度随温度的升高而增大，随甲醇体积分数的增加而减小；L

苯丙氨酸无水物结晶介稳区宽度在相同条件下，随初始温度的升高，降温速率的降低变窄；L

苯丙氨酸转晶水活度随温度的升高而增大。

Abstract

The solubility and supersolubility of L-phenylalanine anhydrate in methanol-water mixed solvent were studied in the temperature range of 293.15—322.15 K

and the crystalline metastable zone of L-phenylalanine anhydrate was obtained. The nucleation order and rate was calculated. Meanwhile

the inﬂuences of temperature and cooling rate on the width of metastable zone were explored. The water activity of transformation at 297.15 K and 302.15 K were measured

the phase diagram of L-phenylalanine-methanol-water at that temperature was obtained through solubility property. The solubility data were correlated by the modified Apelblat equation

λh

equation and van t Hoff equation. The results showed that the solubility of L-phenylalanine obviously increased with the increase of temperature and the decrease of the methanol content; the width of metastable zone decreased with increasing temperature and decreasing cooling rate; the water activity of transformation increased with the increase of temperature.

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references

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甲醇-水溶剂中L-苯丙氨酸结晶热力学

Crystallization thermodynamics of L-phenylalanine in methanol-water solvent

DOI：10.11949/j.issn.0438-1157.20180893

摘要

Abstract

关键词

Keywords

references