Tannin was crosslinked with paraformaldehyde to prepare tannin-phenolic polymer. The spherical poly(tannin)-cellulose resin was synthesized by inversing suspension cross-linking reaction of tannin-phenolic polymer and cellulose with epichlorohydrin as crosslinking agent. The spherical poly(tannin)-cellulose resin was characterized by infrared spectrum(FTIR) and scanning electron microscopy(SEM)

and the adsorption properties of spherical poly(tannin)-cellulose resin for berberine hydrochloride were evaluated. The spherical poly(tannin)-cellulose resin has a porous structure and a large amount of phenolic hydroxyl groups in polymer network. The spherical poly(tannin)-cellulose resin has high adsorption capacity for berberine hydrochloride

the maximum adsorption capacity of berberine hydrochloride on spherical poly(tannin)-cellulose resin was 245.92 mg·g-1 when the initial concentration of berberine hydrochloride was 600 mg·L-1 at 298 K. The adsorption isotherms and kinetics of spherical poly(tannin)-cellulose resin for berberine hydrochloride can be well fitted by the Langmuir equation and pseudo-second-order model

respectively. The data of thermodynamic analysis suggest that the adsorption for berberine hydrochloride on spherical poly(tannin)-cellulose resin was a spontaneous and exothermic physical adsorption process. The spherical poly(tannin)-cellulose resin has a potential application prospect in the field of the separation and purification of alkaloids.