无机纳米药物载体在肿瘤诊疗中的研究进展

康垚; 王素真; 樊江莉; 彭孝军

doi:10.11949/j.issn.0438-1157.20171179

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无机纳米药物载体在肿瘤诊疗中的研究进展

综述与专论 | 更新时间：2025-12-10

- 无机纳米药物载体在肿瘤诊疗中的研究进展
- Progress in inorganic nanomedicine carriers for tumor diagnosis and treatments
- 化工学报 2018年第1期页码：128-140
- 作者机构：
  
  大连理工大学精细化工国家重点实验室,辽宁,大连,116024
- 作者简介：
- 基金信息：
- DOI：10.11949/j.issn.0438-1157.20171179
  中图分类号： 730.59
- 网络首发：2018-01-05，
  
  纸质出版：2018-01-05
- 稿件说明：
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康垚, 王素真, 樊江莉, 等. 无机纳米药物载体在肿瘤诊疗中的研究进展[J]. 化工学报, 2018,(1):128-140.

KANG Yao, WANG Suzhen, FAN Jiangli, et al. Progress in inorganic nanomedicine carriers for tumor diagnosis and treatments[J]. CIESC Journal, 2018, (1): 128-140.
康垚, 王素真, 樊江莉, 等. 无机纳米药物载体在肿瘤诊疗中的研究进展[J]. 化工学报, 2018,(1):128-140. DOI： 10.11949/j.issn.0438-1157.20171179.

KANG Yao, WANG Suzhen, FAN Jiangli, et al. Progress in inorganic nanomedicine carriers for tumor diagnosis and treatments[J]. CIESC Journal, 2018, (1): 128-140. DOI： 10.11949/j.issn.0438-1157.20171179.

摘要

纳米药物作为一种新兴技术，为肿瘤的精确定位和早期诊断、靶向、长效和联合治疗提供了重要的研发平台，为克服传统药物非特异性靶向和非选择性损伤机体组织的瓶颈问题提供了可能。近年来研究者基于量子点、纳米金、纳米介孔硅等无机纳米药物载体设计合成了大量可用于肿瘤诊疗的纳米药物，主要通过“核-壳”结构设计、表面修饰等方法提高纳米药物性能。综述了无机纳米材料作为纳米药物载体在肿瘤诊疗中的应用，详细介绍了纳米药物的设计策略和肿瘤诊疗作用机制，并对未来进行无机纳米药物在肿瘤诊疗中的临床应用进行了展望。

Abstract

Nanomedicine

as an integrated platform

has the potential to accurately monitor tumor for early diagnosis and dramatically improve the targeted

long-lasting and combinational therapy. Compared with traditional therapeutics

nanomedicine would effectively improve the drug accumulationand controlled release in the tumor sites to improve the therapeutic effect. Recently

all kinds of nanomedicines are designed and synthesized for tumor diagnosis and treatment based on inorganic nanocarriers

such as quantum dots

gold nanoparticles

silicon nanoparticles and so on. They might be adjusted and promoted their properties by core-shell structure

surface modification and other strategies. In this review

the inorganic nanometer materials as nano drug carriers applied in tumor diagnosis and treatment were summarized; nano drug design strategies and mechanisms of tumor diagnosis and treatment were introduced in detail

and the future of inorganic nano drugs in tumor diagnosis and treatment of clinical application was prospected.

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