(-)-Ambrox has been recognized as the prototype of all ambergris odorants and used as a valuable ingredient in various flavor and fragrance formulations

because of its unique scent and scent fixative function. In current commercial synthesis processes of (-)-Ambrox

major starting raw materials include sclareol

β-dihydroionone and homofarnesol. All these chemical routes have many problems in terms of green chemistry. This review summarized recent progress in Ambrox synthesis and especially expounded progress with sclareol. Among them

one-pot synthesis using sclareol and hydrogen peroxide in the presence of polyoxometalates catalyst has advantages of easy operation and low pollution

which is a potential green synthetic technique.