This work mainly studied the process of producing 4-(6-hydroxyhexyloxy) phenol with Williamson synthesis in the microreactor. The Box-Behnken model in response surface methodology was used to design the experiments to investigate the effects of reaction temperature

catalyst concentration

reactant ratio

residence time

as well as the interaction among factors

on the yield. The quadratic model was established to correlate the variables to the response values. According to the model

the optimum operating parameters were determined as following temperature 135℃

the concentration of NaOH 2.35 mol·L-1

reactant ratio 2.81

and residence time 2.70 min. Under the optimum conditions

the yield can reach 79.5%

and the error of the predicted and experimental values can be negligible

which showed the accuracy of the model. In addition

a feasible product purification method was proposed

and the structure of the product was confirmed by the 1H NMR spectra.