V2O5@CeO2 core-shell microspheres are prepared by electrostatic self-assembly technique and supported on TiO2. Influences of dispersant (SHP) on zeta potential are investigated. Morphology of obtained microspheres are observed by TEM and FESEM and the catalytic performance for the selective catalytic reduction of NOx with NH3 (NH3-SCR) was investigated in a fixed-bed stainless steel reactor. The catalysts are characterized by BET and in situ DRIFTS analysis of NH3 adsorption. The results show that the nanoparticle surface is negatively charged by dispersant (SHP) and within a certain range

the higher the concentration of SHP is

the greater the zeta potential are. Catalysts with mass fraction of 1% V2O5 and 5% CeO2 show high activity with the NOx conversion over 80% from 260 to 400℃. Compared with catalysts prepared by the traditional impregnation method

the core-shell catalysts present higher SO2 and H2O resistance at low SO2 concentration. When the flue gas contains 571 mg·m-3 SO2 and 15%(vol) H2O

the NOx conversion can be maintained at a high level of 80% after 7 hours.