离子液体中ATRP合成MCC-g-PMAA及其分子对阿司匹林控释的应用

杜煌; 常达; 唐二军; 袁淼; 刘少杰

doi:10.11949/j.issn.0438-1157.20161122

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离子液体中ATRP合成MCC-g-PMAA及其分子对阿司匹林控释的应用

催化、动力学与反应器 | 更新时间：2025-11-26

- 离子液体中ATRP合成MCC-g-PMAA及其分子对阿司匹林控释的应用
- Synthesis of MCC-g-PMAA by ATRP in ILs and its application in controlled release to Aspirin
- 化工学报 2016年第S2期页码：164-170
- 作者机构：
  
  河北科技大学化学与制药工程学院, 河北省药物化工工程技术中心,河北,石家庄,050018
- 作者简介：
- 基金信息：
- DOI：10.11949/j.issn.0438-1157.20161122
  中图分类号： Q469
- 网络首发：2016-12-30，
  
  纸质出版：2016-12-30
- 稿件说明：
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杜煌, 常达, 唐二军, 等. 离子液体中ATRP合成MCC-g-PMAA及其分子对阿司匹林控释的应用[J]. 化工学报, 2016,(S2):164-170.

DU Huang, CHANG Da, TANG Erjun, et al. Synthesis of MCC-g-PMAA by ATRP in ILs and its application in controlled release to Aspirin[J]. CIESC Journal, 2016, (S2): 164-170.
杜煌, 常达, 唐二军, 等. 离子液体中ATRP合成MCC-g-PMAA及其分子对阿司匹林控释的应用[J]. 化工学报, 2016,(S2):164-170. DOI： 10.11949/j.issn.0438-1157.20161122.

DU Huang, CHANG Da, TANG Erjun, et al. Synthesis of MCC-g-PMAA by ATRP in ILs and its application in controlled release to Aspirin[J]. CIESC Journal, 2016, (S2): 164-170. DOI： 10.11949/j.issn.0438-1157.20161122.

摘要

以离子液体氯化1-烯丙基-3-甲基咪唑（[Amim]Cl）为反应介质，利用原子转移自由基聚合（atom transfer radical polymerization，ATRP）法合成了微晶纤维素接枝有聚甲基丙烯酸（MCC-g-PMAA）的pH敏感性聚合物。用透析法将模型药物阿司匹林包覆在聚合物胶束内，并对载药胶束的体外药物释放机制进行研究。通过红外、核磁、透射电镜、X射线衍射和紫外分光光度计等分析手段对聚合物的结构、胶束形貌、胶束对阿司匹林的载药性能及释药性能进行了表征分析。结果表明：聚合物胶束能够在水溶液中自组装成球状胶束，对阿司匹林具有良好的包载效果，阿司匹林在碱性条件下的累积释放量大于酸性条件，载药胶束表现出了良好的pH敏感性和药物缓释性能。

Abstract

Ionic liquid 1-allyl-3-methyl-imidazole chloride ([Amim]Cl) as reaction medium

the microcrystalline cellulose graft poly methylacrylic acid (MCC-g-P4VP) polymer with pH-sensitivity were synthesized by atom transfer radical polymerization (ATRP).The model drug Aspirin was entrapped in polymeric micelles by dialysis method.The release mechanism of drug loaded micelle in vitro was analyzed.The polymer structure

micellar morphology

performance of aspirin loading and drug releasing were characterized by means of FT-IR

1H NMR

TEM

XRD and UV-Vis.The results showed that the micelle could form spherical morphology micelles by self-assembly in aqueous solution

it presented a perfect encapsulation about Aspirin.It was found that the cumulant release of Aspirin in basic environment was higher than that in acidic environment.The drug loaded micelle showed excellent properties of pH-sensitivity and drug sustained-release.

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