Isobaric vapor-liquid equilibrium data of the binary systems isoamyl acetate+isoamyl alcohol and isoamyl acetate+n-hexanol at 50.00 and 101.33 kPa were measured using a vapor-liquid equilibrium still. The isoamyl acetate+isoamyl alcohol system formed a minimum temperature azeotrope at 50.00 kPa. The thermodynamic consistency of the VLE experimental data were checked by Herington method

and the results were satisfied with Gibbs-Duhem's thermodynamic consistency. The experimental measurements for the binary systems were correlated by nonrandom two-liquid (NRTL)

Wilson and universal quasichemical (UNIQUAC) activity coefficient models. Then

the corresponding parameters for the three models were obtained. Compared with the experimental data

the root-mean-square deviations of the boiling temperature and the vapor mole fraction calculated with the correlated parameters were less than 0.20 K and 0.0050

respectively. The calculated results showed that the experimental data agreed well with NRTL

Wilson and UNIQUAC models. Wilson activity coefficient model was used to predict the azeotropic phenomenon of isoamyl acetate+isoamyl alcohol

which indicated that the azeotrope would disappear at 98.4 kPa. This work provided important engineering data for chemical database and further study in the engineering design containing isoamyl acetate.