The amphiphilic and thermosensitive block copolymers can self-assemble and turn into special micron level or nanoscale morphologies in selective solvents

and they have extensive potential applications. Poly(N-isopropyl acrylamide) (PNIPAM) is a typical kind of thermal-sensitive macromolecular material. It can undergo a special “coil to globule” volume phase transition near the lower critical solution temperature in solution. The study of self-assembly of its block copolymers has been drawn great interests. In this paper

self-assembly of PNIPAM block copolymers is introduced. The influence of several aspects including composition

molecular weight

external stimulus conditions and so on is systematically reviewed. Some of its applications on biological medicine

catalysis reaction

etc. are also introduced. The direction of its future development is also forecasted.