Ammoniation of adipic acid is an important method for the production of adiponitrile in industry. The neutralization reaction step is largely affected by the gas-liquid phase mass transfer. The neutralization reaction macrokinetic experiments were conducted in a 1 L semi-continuous stirred reactor. The variation of adipic acid concentration with reaction time was investigated from 210 to 260℃ with 0.2% (mass) phosphoric acid

600 L·h-1 ammonia and 1800 r·min-1 stirring speed. When the concentration of adipic acid was higher than or equal to 0.1 mol·L-1 at 250℃

the neutralization reaction was controlled by mass transfer and it was first-order with respect to adipic acid with activation energy of 42.9 kJ·mol-1. When the concentration of adipic acid in the reactor was lower than 0.1 mol·L-1 at 250℃

the reaction was controlled by reaction and it was second-order under reaction control with activation energy of 52.7 kJ·mol-1. The calculation values and experimental results were matched well

and the intrinsic reaction kinetic order with respect to adipic acid was two according to the theoretical model. Besides

at 260℃

0.2% (mass) phosphoric acid

1800 r·min-1 stirring speed and the same total pressure (slightly greater than the atmospheric pressure)

the variation of adipic acid concentration with reaction time was investigated at a volume flow rate of ammonia between 200 to 600 L·h-1. The results uncovered that the intrinsic reaction kinetic order with respect to ammonia was one.