Chiral chromatography plays an important role in obtaining optically pure enantiomers. The key to preparative chiral chromatography is the availability of chiral stationary phases (CSPs) with broad chiral recognition

high sample loading as well as solvent tolerance. In order to overcome the shortcoming of traditional coating-type or bonding-type cellulose-based CSPs

a novel hybrid CSP based on cellulose derivative bearing a small amount of 3-(triethoxysilyl)propyl groups was proposed

which was used to crosslink with bis(triethoxysilyl)ethane (BTSE) via a sol-gel reaction. The prepared stationary phase was then evaluated by HPLC. The experimental results indicated that the CSP showed excellent chiral recognition ability and could run steadily at back column pressure more than 2000 psi (1 psi 6894.76 Pa) with flow-rate up to 3 ml·min-1 in the mobile phase containing 10% chloroform. It was worth mentioning that the selectivity of 2

2

2-trifluoro-1-(9-anthryl)ethanol and trans-stilbene oxide up to 2.99 and 2.48 was achieved

respectively

confirming its excellent chiral recognition performance. In addition

the reported CSP showed a promising packing for application in preparative chromatography such as simulated moving bed chromatography.