As an important chemical raw material

succinic acid is widely used in many fields of modern industry with a huge market demand. Recently

the biological method for succinic acid fermentation has become a hot topic in research

since it has the advantages of renewable utilization of resources and environmental friendly production. From the perspective of metabolic control

the methods and strategies for succinic acid production with some strains

especially the recombinant E.coli

are summarized in this paper. Regulation of key enzyme gene in metabolism branch and the key factors in fermentation of succinic acid

such as regulation of redox force

carbon dioxide control

and metabolic pathways transforming are introduced. The progress of metabolic control of succinic acid fermentation is presented

and development of succinic acid fermentation in the future is proposed.