Chiral separation by simulated moving bed technology has become an important process. In this work

an advanced simulated moving bed technology (Varicol process) was investigated to separate guaifenesin enantiomers on Chrialcel OD stationary phase using a mixture of ethanol and n-hexane as mobile phase. Based on asynchronous shift of inlet and outlet lines

a mathematical model was established and solved using the finite element model of orthogonal collocation. The evolution of axial internal concentration profile inside the columns was presented to analyze the influence of discrete switch on separation of guaifenesin enantiomers. The separation region of guaifenesin enantiomers by the 5-column (1-1.5-1.5-1) Varicol process was designed

the operating condition of single enantiomer with 99% purities was determined and its feasibility was validated by Varicol experiment. Both experimental and simulated results would facilitate operation and design of the Varicol process.