1.合成生物技术全国重点实验室, 天津300072
2.天津大学合成生物与生物制造学院, 天津300072
杨晶茹(2002—),女,博士研究生,yangjr_2025@tju.edu.cn
王雨佳(2003—),女,硕士研究生,yujiaaa@tju.edu.cn
刘志华(1987—),男,博士,zhliu@tju.edu.cn
收稿:2026-06-13,
修回:2026-07-21,
录用:2026-07-22,
移动端阅览
杨晶茹, 王雨佳, 刘志华. 木质素生物漏斗驱动芳香化学品绿色合成[J/OL]. 化工学报, 2026.
YANG Jingru, WANG Yujia, LIU Zhihua. Lignin biological funneling drives green synthesis of aromatic chemicals[J/OL]. CIESC Journal, 2026.
杨晶茹, 王雨佳, 刘志华. 木质素生物漏斗驱动芳香化学品绿色合成[J/OL]. 化工学报, 2026. DOI: 10.11949/0438-1157.20260816.
YANG Jingru, WANG Yujia, LIU Zhihua. Lignin biological funneling drives green synthesis of aromatic chemicals[J/OL]. CIESC Journal, 2026. DOI: 10.11949/0438-1157.20260816.
木质素作为自然界储量最丰富的可再生芳香聚合物,木质素“生物漏斗”路线通过多酶级联将结构各异的木质素解聚产物定向汇聚为少数或者单一平台化合物。系统综述了基于“生物漏斗”策略的木质素生物转化研究进展,重点阐述了香兰素、原儿茶酸、对羟基苯乙烯等芳香化学品的合成途径与工程化策略,并讨论了合成生物学、人工智能辅助酶工程和代谢调控等前沿技术在推动木质素生物转化应用中的关键作用。该综述有望为木质素生物转化合成高价值产物提供基础理论和关键技术支撑。
Lignin
as the most abundant renewable aromatic polymer in nature. The “biological funnel” pathway directs structurally diverse depolymerization products into a few platform compounds via multi-enzyme cascade. Recent advances in lignin valorization based on the biological funnel strategy are systematically reviewed
with an emphasis on the biosynthetic routes and engineering strategies for aromatic chemicals such as vanillin
protocatechuic acid
and 4-hydroxystyrene. Furthermore
the applications of synthetic biology
artificial intelligence
and enzyme engineering in pathway reconstruction and key enzyme modification are analyzed. To address challenges such as product toxicity and the low conversion efficiency of S-type monomers
future directions including adaptive evolution
intelligent enzyme design
and full-chain synergistic conversion are discussed. This review provides theoretical guidance and a technical reference for the systematic engineering of lignin biological funnel pathways.
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