仲胺类离子液体催化合成甲基丙烯醛反应网络及热力学分析

郑晓妍; 李建辉; 李杰; 王刚; 李增喜; 王二强; 李春山

doi:10.11949/0438-1157.20260412

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仲胺类离子液体催化合成甲基丙烯醛反应网络及热力学分析

催化、动力学与反应器 | 更新时间：2026-05-25

- 仲胺类离子液体催化合成甲基丙烯醛反应网络及热力学分析
- Reaction networks and thermodynamic analysis of methacrolein synthesis catalyzed by sec-amine ionic liquids
- 化工学报 2026年
- 作者机构：
  
  1.中国科学院成都有机化学研究所，四川成都 610041
  2.中国石油大学（北京）化学工程与环境学院，重质油全国重点实验室，北京 102249
  3.中国科学院过程工程研究所，北京市固体锂电池与储能过程重点实验室，介科学与工程全国重点实验室，北京 100190
  4.中国科学院大学化工学院，北京 101408
- 作者简介：
  
  郑晓妍（1999—），女，博士研究生，zhengxiaoyan2021@ipe.ac.cn
  李建辉（1999—），男，硕士研究生，lijianhui990428@163.com
  李杰（1989—），女，博士，副研究员，lijiequst@ipe.ac.cn
- 基金信息：
  
  国家重点研发计划项目(2022YFC3902200);河南省重点研发专项计划项目(241111230500)
- DOI：10.11949/0438-1157.20260412
  中图分类号： O 643.32
- 收稿：2026-03-27，
  
  修回：2026-05-19，
  
  录用：2026-05-20，
- 稿件说明：
移动端阅览
郑晓妍, 李建辉, 李杰, 等. 仲胺类离子液体催化合成甲基丙烯醛反应网络及热力学分析[J/OL]. 化工学报, 2026.

ZHENG Xiaoyan, LI Jianhui, LI Jie, et al. Reaction networks and thermodynamic analysis of methacrolein synthesis catalyzed by sec-amine ionic liquids[J/OL]. CIESC Journal, 2026.
郑晓妍, 李建辉, 李杰, 等. 仲胺类离子液体催化合成甲基丙烯醛反应网络及热力学分析[J/OL]. 化工学报, 2026. DOI： 10.11949/0438-1157.20260412.

ZHENG Xiaoyan, LI Jianhui, LI Jie, et al. Reaction networks and thermodynamic analysis of methacrolein synthesis catalyzed by sec-amine ionic liquids[J/OL]. CIESC Journal, 2026. DOI： 10.11949/0438-1157.20260412.

摘要

近年来，仲胺离子液体催化甲醛与丙醛经Mannich缩合反应制备甲基丙烯醛（MAL）受到广泛关注。针对该均相反应体系，筛选出

-乙基环己胺丁酸盐离子液体为最优催化剂。采用气相色谱-质谱联用技术（GC-MS）对反应体系中的主及副产物进行结构鉴定，构建了由目标反应及主要副反应组成的反应网络。利用基团贡献法估算了相关物质的基础热力学参数，并对不同方法得到的结果进行了对比分析，进而计算了各反应的吉布斯自由能变与平衡常数。本工作为仲胺离子液体催化甲醛-丙醛缩合制备MAL反应路径研究和催化体系优化提供了理论依据。

Abstract

In recent years

the synthesis of methacrolein (MAL) from formaldehyde and propionaldehyde

via

Mannich reaction catalyzed by sec-amine ionic liquids has attracted considerable attention. In this homogeneous reaction system

-ethylcyclohexylamine butyrate ionic liquid was identified as th

e optimal catalyst. The main products and byproducts were structurally identified by gas chromatography-mass spectrometry (GC-MS)

and a reaction network composed of the target reaction and the main side reactions was constructed. The basic thermodynamic properties of the relevant substances were estimated using group contribution methods

and the results obtained from different methods were comparatively analyzed. On this basis

the Gibbs free energy changes and equilibrium constants of the individual reactions were calculated. This work provides a theoretical basis for elucidating the reaction pathways and optimizing the catalytic system for MAL synthesis from formaldehyde and propionaldehyde over sec-amine ionic liquids.

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references

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