NH<sub>2</sub>-MCM-41的改性及其pH响应性释药的研究

徐彦芹; 秦钊; 王烨; 曹渊; 陈昌国; 王丹

doi:10.11949/0438-1157.20191604

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NH₂-MCM-41的改性及其pH响应性释药的研究

生物化学工程与技术 | 更新时间：2025-11-25

- NH₂-MCM-41的改性及其pH响应性释药的研究
- Study on modification of NH₂-MCM-41 and its pH-responsive drug release
- 化工学报 2020年71卷第10期页码：4783-4791
- 作者机构：
  
  1.重庆大学化学化工学院，重庆 401331
  2.重庆大学煤矿灾害动力学与控制国家重点实验室，重庆 401331
- 作者简介：
  
  徐彦芹（1984—），女，硕士，高级工程师，xuyanqin666@163.com
  秦钊（1996—），男，硕士研究生，201918131134@ cqu.edu.cn
  曹渊（1963—），男，博士，教授，caoyuan@cqu.edu.cn
  王丹（1982—），女，博士，副教授，dwang@cqu.edu.cn
- 基金信息：
  
  国家自然科学基金项目(21978027)
- DOI：10.11949/0438-1157.20191604
  中图分类号： O 643.36
- 收稿：2020-01-02，
  
  修回：2020-06-11，
  
  纸质出版：2020-10-05
- 稿件说明：
移动端阅览
徐彦芹, 秦钊, 王烨, 曹渊, 陈昌国, 王丹. NH₂-MCM-41的改性及其pH响应性释药的研究[J]. 化工学报, 2020, 71(10): 4783-4791 DOI: 10.11949/0438-1157.20191604.

XU Yanqin, QIN Zhao, WANG Ye, CAO Yuan, CHEN Changguo, WANG Dan. Study on modification of NH₂-MCM-41 and its pH-responsive drug release[J]. CIESC Journal, 2020, 71(10): 4783-4791 DOI: 10.11949/0438-1157.20191604.
徐彦芹, 秦钊, 王烨, 曹渊, 陈昌国, 王丹. NH₂-MCM-41的改性及其pH响应性释药的研究[J]. 化工学报, 2020, 71(10): 4783-4791 DOI: 10.11949/0438-1157.20191604. DOI：

XU Yanqin, QIN Zhao, WANG Ye, CAO Yuan, CHEN Changguo, WANG Dan. Study on modification of NH₂-MCM-41 and its pH-responsive drug release[J]. CIESC Journal, 2020, 71(10): 4783-4791 DOI: 10.11949/0438-1157.20191604. DOI：

摘要

采用正硅酸乙酯（TEOS）和3-氨丙基三乙氧基硅烷（APTES）通过共缩聚法合成介孔二氧化硅（MCM-41）。首先对其氨基修饰，再通过有机合成接枝—R基团（—R：—CHO、—OH、—CH

、—COOH），制备得到Me-Ph-NH-MCM-41、OHC-Ph-NH-MCM-41、HO-Ph-NH-MCM-41、HOOC-Ph-NH-MCM-41四种不同的药物载体。利用FT-IR、Zeta电位、XRD和SEM对其结构和形貌表征，结果表明NH

-MCM-41改性成功。以罗丹明B（RhB）为模型进行载药性能测试，并考察了此释药系统在模拟不同pH的体液下的敏感释药行为，同时探究了不同—R基团对释药的影响。结果显示，四种载体在中性条件下几乎不发生药物释放，通过改变环境体系pH可以有效控制药物释放，其释药行为可以用Korsmeyer-Peppas动力学模型来描述。实验表明，释药量：RhB@HOOC-Ph-NH-MCM-41

RhB@OHC-Ph-NH-MCM-41

RhB@HO-Ph-NH-MCM-41

RhB@Me-Ph-NH-MCM-41，不同—R基团的药物载体的pH响应性不同，其中RhB@HOOC-Ph-NH-MCM-41释药量在pH=1.2时可达57.87%，在用于药物智能控释材料方面具有一定的应用潜力。

Abstract

Mesoporous silica (MCM-41) was synthesized by copolycondensation of tetraethoxysilane (TEOS) and 3-aminopropyltriethoxysilane (APTES). Firstly

it was modified with amino group. Then

four different drug carriers

Me-Ph-NH-MCM-41

OHC-Ph-NH-MCM-41

HO-Ph-NH-MCM-41

and HOOC-Ph-NH-MCM-41

were synthesized by grafting —R group (—R: —CHO

—OH

—CH

—COOH)

respectively. FT-IR

SEM

Zeta potential

and XRD were used to characterize its structure and morphology

indicating the successful synthesis of modified MCM-41. Rhodamine B (RhB) was used as a model for drug loading performance testing and the sensitive drug release behavior of this drug release system under different pH simulated humors was investigated. The effects of different —R groups on drug release were also explored. The results show that the four carriers hardly release drugs under neutral conditions. The drug release can be effectively controlled by changing the pH of the environmental system. The drug release behavior can be described by the Korsmeyer-Peppas kinetic model. The experiment showed that the drug release amount: RhB@HOOC-Ph-NH-MCM-41

RhB@OHC-Ph-NH-MCM-41

RhB@HO-Ph-NH-MCM-41

RhB@Me-Ph-NH-MCM-41. The pH-response of drug carriers with different —R groups was different

and the drug release amount of RhB@HOOC-Ph-NH-MCM-41 reached 57.87% at pH = 1.2

which has some potential applications in intelligent controlled release materials of drugs.

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Keywords

references

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NH2-MCM-41的改性及其pH响应性释药的研究

Study on modification of NH2-MCM-41 and its pH-responsive drug release

DOI：10.11949/0438-1157.20191604

摘要

Abstract

关键词

Keywords

references

NH₂-MCM-41的改性及其pH响应性释药的研究

Study on modification of NH₂-MCM-41 and its pH-responsive drug release