TiO<sub>2</sub>纳米管阵列粗糙度调控及其与蛋白相互作用

吴娜; 董依慧; 吉晓燕; 皇甫长安; 陆小华

doi:10.11949/0438-1157.20190954

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TiO₂纳米管阵列粗糙度调控及其与蛋白相互作用

材料化学工程与纳米技术 | 更新时间：2026-07-24

- TiO₂纳米管阵列粗糙度调控及其与蛋白相互作用
- Interaction between proteins and roughness-regulated TiO₂ nanotube arrays
- 化工学报 2020年71卷第2期页码：831-842
- 作者机构：
  
  1. 南京工业大学材料化学工程国家重点实验室，江苏南京 210009
  2. 吕勒奥工业大学能源工程系，瑞典吕勒奥 97187
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(21838004)
- DOI：10.11949/0438-1157.20190954
  中图分类号： TQ 01
- 收稿：2019-08-21，
  
  修回：2019-11-13，
  
  网络首发：2020-08-14，
  
  纸质出版：2020-02-05
- 稿件说明：
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吴娜, 董依慧, 吉晓燕, 皇甫长安, 陆小华. TiO₂纳米管阵列粗糙度调控及其与蛋白相互作用[J]. 化工学报, 2020, 71(2): 831-842 DOI: 10.11949/0438-1157.20190954.

WU Na, DONG Yihui, JI Xiaoyan, HUANGFU Chang an, LU Xiaohua. Interaction between proteins and roughness-regulated TiO₂ nanotube arrays[J]. CIESC Journal, 2020, 71(2): 831-842 DOI: 10.11949/0438-1157.20190954.
吴娜, 董依慧, 吉晓燕, 皇甫长安, 陆小华. TiO₂纳米管阵列粗糙度调控及其与蛋白相互作用[J]. 化工学报, 2020, 71(2): 831-842 DOI: 10.11949/0438-1157.20190954. DOI：

WU Na, DONG Yihui, JI Xiaoyan, HUANGFU Chang an, LU Xiaohua. Interaction between proteins and roughness-regulated TiO₂ nanotube arrays[J]. CIESC Journal, 2020, 71(2): 831-842 DOI: 10.11949/0438-1157.20190954. DOI：

摘要

采用电化学阳极氧化法，通过改变电解液氟离子浓度(0.4%、0.3%、0.2%(质量))和电压(15、25、35、45 V)，制备一系列不同管径和粗糙度的TiO

纳米管阵列(TiO

nanotube arrays

TNAs)。通过扫描电子显微镜以及原子力显微镜(atomic force microscopy

AFM)表征，结果表明随着电解液中氟离子浓度的降低，制备得到的TNAs表面平整度更好，壁厚增大，粗糙度降低。采用AFM力学表征研究了表面粗糙度以及管径对TNAs表面力学性质以及与细胞色素C(Cytochrome C

Cyt C)相互作用的影响，结果表明，黏附力与接触面积呈正比，随着TNAs管径增加，壁厚减小，TNAs与Cyt C的有效接触面积先增大后减小，两者之间作用力也先增加后减小；同时，同管径条件下粗糙度降低，TNAs有效面积增加，相互作用力也增加；由此可见，通过改变电解液氟离子浓度可以有效调控TNAs表面粗糙度及有效接触面积，进一步利于促进与蛋白分子之间相互作用。

Abstract

A series of TiO

nanotube arrays (TNAs) with different diameters and roughness were prepared by electrochemical anodization method by changing the fluoride ion concentration [0.4%

0.3%

0.2%(mass)

]

and applied voltage(15

45 V). The scanning electron microscopy (FESEM) and atomic force microscopy (AFM) results showed that the wall thickness of the prepared TNAs increased and the roughness decreased with the decrease of fluoride ion concentration in the electrolyte. The effects of surface roughness and diameter on the surface mechanical properties of TNAs and the interaction of Cytochrome C (Cyt C) were studied by AFM characterization. The results show that the adhesion is proportional to the contact area. With the increase of the diameter of the TNAs

the wall thickness decreases

the effective contact area between TNAs and Cyt C increases first and then decreases，and the forces of Cyt C with TNAs also increase first and then decrease. The roughness decreases when the diameter was fixed

the effective area of TNAs increases

and

the interaction force also increases. It can be seen that the surface roughness and effective contact area of TNAs can be effectively controlled by changing the fluoride ion concentration of the electrolyte

which is further beneficial to promoting interaction with protein molecules.

关键词

Keywords

references

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TiO2纳米管阵列粗糙度调控及其与蛋白相互作用

Interaction between proteins and roughness-regulated TiO2 nanotube arrays

DOI：10.11949/0438-1157.20190954

摘要

Abstract

关键词

Keywords

references

TiO₂纳米管阵列粗糙度调控及其与蛋白相互作用

Interaction between proteins and roughness-regulated TiO₂ nanotube arrays