稻草秸秆综纤维素对阿司匹林片崩解性能的影响

李双凤; 王淮; 陈家丽; 姚日生; 朱慧霞; 马晓静

doi:10.11949/0438-1157.20190466

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稻草秸秆综纤维素对阿司匹林片崩解性能的影响

能源和环境工程 | 更新时间：2020-06-24

- 稻草秸秆综纤维素对阿司匹林片崩解性能的影响
- Effect of rice straw holocellulose on disintegration of aspirin tablets
- 化工学报 2019年70卷第11期页码：4420-4427
- 作者机构：
  
  1.合肥工业大学食品与生物工程学院，安徽合肥 230009
  2.农产品生物化工教育部工程研究中心,安徽合肥 230009
- 作者简介：
  
  李双凤(1995—)，女，硕士研究生，1191274253@qq.com
  王淮 (1976—)，男，博士，副教授，whuai76@hfut.edu.cn
- 基金信息：
  
  国家高技术研究发展计划项目(SS2014AA021902)
- DOI：10.11949/0438-1157.20190466
  中图分类号： TB 32
- 收稿：2019-05-06，
  
  修回：2019-08-05，
  
  纸质出版：2019-11-05
- 稿件说明：
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李双凤, 王淮, 陈家丽, 姚日生, 朱慧霞, 马晓静. 稻草秸秆综纤维素对阿司匹林片崩解性能的影响[J]. 化工学报, 2019, 70(11): 4420-4427

LI Shuangfeng, WANG Huai, CHEN Jiali, YAO Risheng, ZHU Huixia, MA Xiaojing. Effect of rice straw holocellulose on disintegration of aspirin tablets[J]. CIESC Journal, 2019, 70(11): 4420-4427
李双凤, 王淮, 陈家丽, 姚日生, 朱慧霞, 马晓静. 稻草秸秆综纤维素对阿司匹林片崩解性能的影响[J]. 化工学报, 2019, 70(11): 4420-4427 DOI： 10.11949/0438-1157.20190466.

LI Shuangfeng, WANG Huai, CHEN Jiali, YAO Risheng, ZHU Huixia, MA Xiaojing. Effect of rice straw holocellulose on disintegration of aspirin tablets[J]. CIESC Journal, 2019, 70(11): 4420-4427 DOI： 10.11949/0438-1157.20190466.

摘要

以稻草秸秆为原料，经过SO

微热爆预处理、木质素降解、漂白等工序制备出了稻草秸秆综纤维素，并将其用作片剂崩解剂进行了性能评价。参照《中国药典》(2015版)中的有关规定，检测了稻草秸秆综纤维素的各项指标；以阿司匹林为模型药物，以市售微晶纤维素为对照，测定了稻草秸秆综纤维素的崩解性能。结果表明，稻草秸秆综纤维素质量符合《中国药典》(2015版)中的相关规定，且崩解性明显优于市售微晶纤维素，可用作片剂崩解剂。在稻草秸秆综纤维素用量为3％~5%时即可达到微晶纤维素用量为15%~20%的崩解效果，这一效果的呈现与稻草秸秆综纤维素的形态结构以及含有半纤维素组分有着密切联系。

Abstract

Rice straw holocellulose

prepared from biomass rice straw by SO

micro-thermal explore

degradation of lignin and bleaching

was used as tablet disintegrating agent. The performance was evaluated by using it as a tablet disintegrating agent. According to the relevant standards of Chinese Pharmacopoeia (2015 Edition)

several characters of rice straw holocellulose

such as surface morphology

specific surface area

etc

were detected. Taking aspirin as model drug

the disintegration performance of rice straw holocellulose was determined and compared with commercial microcrystalline cellulose. The results showed that the quality of rice straw holocellulose was in accordance with the relevant regulations of Chinese Pharmacopoeia

and the disintegration of rice straw holocellulose was obviously superior to that of commercial microcrystalline cellulose. The same disintegration effect with 15%—20% microcrystalline cellulose can be attained by using only 3%—5% rice straw holocellulose. This result should be closely owed to the structure and semicellulose of rice straw holocellulose.

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