用微反应器实现可见光驱动的不对称氧化连续化反应

冯世豪; 唐晓飞; 都健; 孟庆伟

doi:10.11949/0438-1157.20190189

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用微反应器实现可见光驱动的不对称氧化连续化反应

更新时间：2026-07-24

- 用微反应器实现可见光驱动的不对称氧化连续化反应
- Asymmetric continuous oxidation in microreactor driven by visible light
- 化工学报 2019年70卷第8期页码：3202-3209
- 作者机构：
  
  1.大连理工大学化工学院,精细化工国家重点实验室，辽宁大连 116024
  2.大连理工大学化工系统工程研究所，辽宁大连 116024
- 作者简介：
  
  冯世豪(1994—)，男，硕士研究生，liwupu000@126.com
  孟庆伟(1964—)，男，硕士，教授，mengqw@dlut.edu.cn
- 基金信息：
  
  国家自然科学基金项目(21476041;U1608224;61633006)
- DOI：10.11949/0438-1157.20190189
  中图分类号： TQ 460.31
- 收稿：2019-03-05，
  
  修回：2019-05-13，
  
  网络首发：2026-07-24，
  
  纸质出版：2019-08-05
- 稿件说明：
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冯世豪, 唐晓飞, 都健, 孟庆伟. 用微反应器实现可见光驱动的不对称氧化连续化反应[J]. 化工学报, 2019, 70(8): 3202-3209

FENG Shihao, TANG Xiaofei, DU Jian, MENG Qingwei. Asymmetric continuous oxidation in microreactor driven by visible light[J]. CIESC Journal, 2019, 70(8): 3202-3209
冯世豪, 唐晓飞, 都健, 孟庆伟. 用微反应器实现可见光驱动的不对称氧化连续化反应[J]. 化工学报, 2019, 70(8): 3202-3209 DOI： 10.11949/0438-1157.20190189.

FENG Shihao, TANG Xiaofei, DU Jian, MENG Qingwei. Asymmetric continuous oxidation in microreactor driven by visible light[J]. CIESC Journal, 2019, 70(8): 3202-3209 DOI： 10.11949/0438-1157.20190189.

摘要

将可见光催化、不对称合成、分子氧氧化和连续化集成，创新性地用玻璃微通道反应器实现可见光活化分子氧氧化的

-酮酸酯类化合物的不对称

-羟基化反应的连续工艺。用金鸡纳碱衍生的相转移有机催化剂在气-液-液多相体系内实现可见光催化，分子氧不对称氧化连续反应。在心形微通道反应器内，1-茚酮-2-甲酸金刚酯底物完全氧化为(

)-2-羟基-1-茚酮-2-甲酸金刚酯，产物收率95%，对映选择性87.0%。与间歇反应相比，采用微反应器的连续反应在保持产物高立体选择性基础上将30 min反应停留时间缩短至1.08 min。该方法具有快速、低能耗、连续、高效等优势，具有良好的工业化前景。

Abstract

Photocatalysis

asymmetric synthesis and molecular oxygen oxidation are combined with continuous reaction. Using a glass microreactor

a continuous reaction for asymmetric

-hydroxylation of

-keto ester compound is oxidized by

under visible light. The reaction is catalyzed by cinchona alkaloid phase transfer catalyst in gas-liquid-liquid heterogeneous system. The desired product is obtained in high yield (95%) and good enantio selectivity (87.0%) in microreactor. Compared with the batch reaction

continuous reaction greatly reduces reaction residence time from 30 min to 1.08 min and maintains high stereo selectivity. The method has the advantages of fast

low energy consumption

continuous and high efficiency

and has good industrialization pros

pects.

关键词

Keywords

references

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