新型药物载体聚乙烯-聚丙交酯载药颗粒的制备及表征

姜维; 王运东; 张建铮; 甘泉; 张汉威; 贝建中; 赵秀文; 费维扬

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新型药物载体聚乙烯-聚丙交酯载药颗粒的制备及表征

材料科学与工程 | 更新时间：2026-03-26

- 新型药物载体聚乙烯-聚丙交酯载药颗粒的制备及表征
- Preparation and characterization of biodegradable nanoparticles from methoxy poly(ethylene glycol)- poly (D,L-lactide)block copolymers as novel drug carriers
- 化工学报 2006年57卷第2期
- 作者机构：
  
  清华大学化工系化学工程联合国家重点实验室
- 作者简介：
- 基金信息：
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- 网络首发：2006-02-25，
  
  纸质出版：2006
- 稿件说明：
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姜维, 王运东, 张建铮, 等. 新型药物载体聚乙烯-聚丙交酯载药颗粒的制备及表征[J]. 化工学报, 2006,57(2).

JIANG Wei, WANG Yundong, ZHANG Jianzheng, et al. Preparation and characterization of biodegradable nanoparticles from methoxy poly(ethylene glycol)- poly (D,L-lactide)block copolymers as novel drug carriers[J]. CIESC Journal, 2006, 57(2).
姜维, 王运东, 张建铮, 等. 新型药物载体聚乙烯-聚丙交酯载药颗粒的制备及表征[J]. 化工学报, 2006,57(2). DOI：

JIANG Wei, WANG Yundong, ZHANG Jianzheng, et al. Preparation and characterization of biodegradable nanoparticles from methoxy poly(ethylene glycol)- poly (D,L-lactide)block copolymers as novel drug carriers[J]. CIESC Journal, 2006, 57(2). DOI：

摘要

Abstract

Methoxy poly(ethylene glycol)-poly(D

L-lactide) block copolymers (PEG-PLA) were prepared through ring-opening polymerization.The oil in water suspension method was used to prepare block copolymer micelles. The critical micelle concentration (CMC) by fluorescence spectroscopy was 0.0056 mg8226;ml-1. The physical state of the inner core region of micelles was characterized with 1HNMR. The size of indomethacin (IMC) loaded micelles measured by dynamic light scattering (DLS) showed narrow monodisperse size distribution and the average diameters were less than 50 nm. In addition

the nanoparticles with relatively high drug loading content (DLC) were obtained.

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