Yang Zhifa, Yu Shuqiu Liu Shouxin and Wang Jianxinand Chen Jiayong(Institute of Chemical Metallurgy, Academia Sinica, et al. Demulsification by Aluminium Sulfate Flocculant During Extraction of Penicillin G from the Filtrate of Fermentation Broth[J]. CIESC Journal, 1991, (6).
Yang Zhifa, Yu Shuqiu Liu Shouxin and Wang Jianxinand Chen Jiayong(Institute of Chemical Metallurgy, Academia Sinica, et al. Demulsification by Aluminium Sulfate Flocculant During Extraction of Penicillin G from the Filtrate of Fermentation Broth[J]. CIESC Journal, 1991, (6).DOI:
On the basis of characteristics of Al(III)and proteins in aqueous solutions
the demulsification effect and operating conditions during extraction of penicillin G from the filtrate of fermentation broth with aluminium sulfate as demulsifier have been studied. If aluminium sulfate was premixed with the filtrate for 30 seconds with pH>4.5 before extraction and then kept at pH> 3.0
the demulsification ability of 0.1-0.3% (wt/v) aluminium sulfate was as good as that of alkyl trimethyl ammonium bromides with the pH strictly controlled at the required value. The quality of penicillin G product with ala-minum sulfate as demulsifier was also found to be good.