2

6-Difluorobenzamide is an important organic reaction intermediate that is mainly used for synthesizing fluor-benzylacylurea class pesticide intermediate. One of the methods for 2

6-difluorobenzamide preparation is inorganic acid/base catalyzed hydrolysis of 2

6-difluorobenzonitrile，which causes serious waste water pollution. A green preparation technology of non-catalytic hydrolysis of 2

6-difluorobenzonitrile to 2

6-difluorobenzamide in high temperature liquid water was studied in this work. 2

6-Difluorobenzonitrile hydrolysis is typical consecutive reactions with 2

6-difluorobenzamide and 2

6-difluorobenzoic acid as intermediates and m -difluorobenzene as the final product. The hydrolysis kinetics of 2

6-difluorobenzonitrile and 2

6-difluorobenzamide，decarboxylation kinetics of 2

6-difluorobenzoic acid were determined at different initial concentrations and temperatures. With consecutive first-order kinetics models，the apparent activation energies evaluated were 96.7 kJ·mol-1 for 2

6-difluorobenzonitrile hydrolysis and 75.4 kJ·mol-1 for 2

6-difluorobenzamide hydrolysis，and 184.3 kJ·mol-1 for 2

6-difluorobenzoic acid decarboxylation. A yield of 64.27% of 2

6-difluorobenzamide could be reached at 523.15 K and reaction time of 300 min，which proved the technical feasibility of non-catalytic hydrolysis of 2

6-difluorobenzonitrile to 2

6-difluorobenzamide in high temperature liquid water. The results could provide important basic data for the green preparation of 2

6-difluorobenzamide as well as the study of hydrolysis of nitriles in high temperature liquid water.