Parameter setting optimization in the injection molding process was studied in this paper. Aggressive space mapping method was used to reduce time and cost of the experiment. An improved aggressive space mapping method was proposed to solve the problem when a fairly large difference of the response value space existed between the coarse model and the fine model. A new parameter extraction method was proposed. Aggressive space mapping method and output space mapping method were combined. The differences of both the parameter space and the response value space were taken into account. The proposed method was applied to the Moldflow analysis software
and the product size was used as quality index. Optimal injection molding parameters were obtained with less time and cost.