The distribution of ibuprofen enantiomers was examined in aqueous methanol solution and 1

2-dichloroethane organic solvent containing a chiral selector hydrophobic L-tartaric ester or D-tartaric ester.The influences of the length of alkyl chain of L-tartaric ester or D-tartaric ester

the concentration of L-tartaric ester

different organic solvents and the concentration of aqueous methanol solution on the partition coefficient(K) and separation factor(α) of ibuprofen

were investigated.L-tartaric ester formed more stable complex with Ⅱ-ibuprofen than with Ⅰ-ibuprofen.In contrast

D-tartaric ester formed more stable complex withⅠ-ibuprofen than with Ⅱ-ibuprofen.The extraction performance of organic solvents was different.For example

alcohols＞1

2-dichloroethane＞alkanes.K and αwere the highest when the concentration of aqueous methanol solution was 10%.With further increasing concentration of aqueous methanol solution

partition coefficient and separation factor decreased.With increasing concentration of L-tartaric ester

K and αincreased firstly

and then decreased.K and αwere the highest

when the concentration of L-tartaric ester was 0.2 mol·L-1.The length of alkyl chain of L-tartaric esters and D-tartaric esters also had a great influence on K and α.