Selective oxidation of dimethyl ether(DME)to dimethoxyethane(DMET)and other hydrocarbons over SnO2/MgO and V or Mn modified catalysts was investigated. It was found that all the catalysts were active for the reaction in the temperature range of 275—325℃. DME conversion and the selectivity of DMET increased when adding V or Mn to the SnO2/MgO catalyst. The selectivity of DMET reached 44% at a DME conversion of 23% on VOx/SnO2/MgO catalyst,which is higher than those of SnO2/MgO or Mn modified SnO2/MgO catalysts.