Genetic algorithm was used to estimate the kinetics parameters for the synthesis of ethyl tert -butyl ether from ethanol and tert -butyl alcohol on strong acid cation exchange resin S-54.The standard genetic algorithm was modified by using multiple crossover and mutation strategies instead of simple strategy.The modified genetic algorithm avoided the problem of local optimum and showed higher estimation precision and better convergence than the traditional algorithm of Runge-Kutta.The influences of genetic strategy and the genetic code representation on algorithm performance were also discussed.The calculation results using these parameters obtained with the modified genetic algorithm agreed well with experimental data.