An adsorption dynamics model for large biomolecules is devloped by using RSA LRS theory The calculated values are obtained by orthogonal collocation method(OCM) The special features as large molecules and biological activity are considered during set up of mathematical model The predicted results are in good agreement with experimental data It is indicated that the mathematical model is suitable for the mass tranfer of LDL and VLDL The simulation computation can be used for designing

operation and optimizing the adsoption system in clinical treatment