The design and calculation of the integrated process of distillation and pervaporation for the separation of MTBE/C4/methanol mixture was carried out with the HYSIM modeling system. The component concentration profiles and temperature distributions in the distillation column were obtained. The integrated process for different draw streams taken from the distillation column was also calculated. The results show that the integrated process with side draw stream is much better than that of the stream taken from the top of the distillation column. The methanol mole fraction in the top product was reduced to 9.07 × 10 - 5 for the integrated process. The water scrubbing process was eliminated and much energy could be saved in comparison with the conventional process.