Traditional Fenton oxidation process uses ferrous iron (Fe2+) as catalyst.Fenton-like reactions using iron minerals as heterogeneous catalysts has caught attention recently.However，Fenton-like reaction using pyrite cinder as catalyst was not reported in early research.The catalytic activity of pyrite cinder for pollutants oxidation was evaluated by using Acid Red B，phenol and industrial wastewater as model organic contaminants.The effect of catalyst and H2O2 dosage，initial pH，reaction time，reusability of catalyst on the oxidation was investigated.When the concentration of pyrite cinder and H2O2 dosage were 10 g·L-1 and 20 ml·L-1 respectively，the removal efficiencies of Acid Red B and phenol were almost 100% in a broad range of pH value from 1 to 11.Obvious decolorization of industrial wastewater was observed within 6 h，and the ratio of BOD5/COD increased greatly.The results indicated that unlike traditional Fenton reagent，the reaction of pyrite cinder with H2O2 could effectively catalyze the oxidation of organic contaminants at circumneutral pH.This process avoids the initial acidification.In addition，pyrite cinder exhibited higher activity than other pure iron oxide minerals.The catalyst could be easily recovered by sedimentation or filtration for further use.