Hydrophobic CuO/TiO2 was prepared from nano-CuO/TiO2 and sodium dodecyl sulfate（SDS).The influences on photocatalytic degradation of nitrobenzene using these catalysts under visible light irradiation were investigated.Characterization of the catalyst showed that SDS-CuO/TiO2 photocatalysts had complete diffraction peaks of anatase and CuO crystalloids，its UV-Vis absorption performances had nothing to do with the variations of SDS loadings，and hydrophobic sites on the catalysts surfaces were mostly long chain alkyls.Experiments indicated six factors having influence on the degradation of nitrobenzene and their best levels were determined respectively.SDS loading was 2.3 g8226;（2.5 g TiO2)-1.Initial concentration of nitrobenzene ranged from 400—500 mg8226;L-1.Dosage of catalysts and H2O2 were 0.2 g8226;L-1 and 6 ml8226;L-1，respectively.pH was 9.Under these conditions，nitrobenzene degradation ratio was about 80% after irradiation for 2 h and 93% for 4 h.