A novel synthesis process of 5H-dibenz［b

f］azepine was studied.It is an important intermediate of 5H-dibenz［b

f］azepine-5-carboxamide

used in genetic engineering

materials science and so on.With 10

11-dihydro-5H-dibenz［b

f］azepine as raw material

5-chloroformyl-5H-dibenz［b

f］azepine was prepared by reflux with triphosgene in toluene

brominated with bromine in chlorobenzene

and dehydrobrominated at 130℃

finally

the title compound was obtained by removing chloroformyl group with NaOH in isopropanol with 80.4% overall yield.The optimal reaction conditions and yields (temperature

time

molar yield) were as follows: acyl chlorination

110℃

10 h

93.0%;bromination

dehydrobromination

100℃

2 h

130℃

5 h

88.0%;removal of chloroformyl group

40℃

3 h

98.2%. The melting point of the title compound was the same as literature reported

and its structure was confirmed by 1H NMR.The optimal technology condition to remove chloroformyl group as protection group and its application of protection for some amine compounds were also studied.