Bubble behavior was observed by using high-speed digital camera in a two-dimensional rectangular bubble column of 0.20 m（width）× 0.02 m（thickness）× 2.00 m（height）.Air and water were used as gas and liquid phases，respectively.Hydrodynamic simulation was conducted in the platform of commercial software package，ANSYS CFX 10.0，by combining the classical two-fluid model of turbulence and GRACE drag model.The computational distributions of bubble size from the MUSIG（multiple size group）model considering bubbles breakup and coalescence were in good agreement with experimental data，which showed that this model could be used to predict the bubble size distribution in the gas-liquid bubble column.