胸腺素α<sub>1</sub>的DIC固相化学合成与鉴定

甘一如; 黄永东; 刘晋生; 张雪竹; 张贵峰

您当前的位置：

首页 >

文章列表页 >

胸腺素α₁的DIC固相化学合成与鉴定

生物化学工程、制药、食品和天然产物加工 | 更新时间：2025-12-10

- 胸腺素α₁的DIC固相化学合成与鉴定
- THYMOSIN α_１ SYNTHESIS WITH DIC AND ITS IDENTIFICATION
- 化工学报 2004年第2期页码：305-308
- 作者机构：
  
  1. 天津大学化工学院,天津,300072
  2. 中国科学院过程工程研究所生化工程国家重点实验室,北京,100080
- 作者简介：
- 基金信息：
- DOI：
  中图分类号：
- 网络首发：2004-02-25，
  
  纸质出版：2004-02-25
- 稿件说明：
移动端阅览
甘一如, 黄永东, 刘晋生, 等. 胸腺素α₁的DIC固相化学合成与鉴定[J]. 化工学报, 2004,(2):305-308.

GAN Yiru, HUANG Yongdong, LIU Jinsheng, et al. THYMOSIN α_１ SYNTHESIS WITH DIC AND ITS IDENTIFICATION[J]. CIESC Journal, 2004, (2): 305-308.
甘一如, 黄永东, 刘晋生, 等. 胸腺素α₁的DIC固相化学合成与鉴定[J]. 化工学报, 2004,(2):305-308. DOI：

GAN Yiru, HUANG Yongdong, LIU Jinsheng, et al. THYMOSIN α_１ SYNTHESIS WITH DIC AND ITS IDENTIFICATION[J]. CIESC Journal, 2004, (2): 305-308. DOI：

摘要

Abstract

Thymosin α1 was synthesized manually. The washing condition and the test of the degree of coupling were studied. In addition

the analytical method of crude product was set up. Thymosin α1 was synthesized with the solid-phase method

by using the base-liable Fmoc group to protect the α-amino acid and N

N′-diisopropylcarbodiimide (DIC) as the coupling regent. The crude product was analyzed by reversed-phase high performance liquid chromatography

SDS-PAGE and liquid chromatography/mass spectroscopy.The synthesis yield was 84.89%. The analytical results indicated that the crude product contained much thymosin α1

and the purity was 50.3%. DIC solid-phase chemical synthesis of thymosin α1 was applicable

and the yield was improved greatly compared to other known methods.

关键词

Keywords

references

浏览量

648

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

应用液相色谱法分离纯化固相化学合成胸腺素α1

基于机器学习的改型歧管式微通道热沉流动传热特性多目标优化

旋流式冷却造粒塔的优势与风险分析

温和条件下太阳能光热催化氨合成与分解的研究进展

硫氰酸红霉素溶解动力学研究

胸腺素α1的DIC固相化学合成与鉴定

THYMOSIN α１ SYNTHESIS WITH DIC AND ITS IDENTIFICATION

DOI：

摘要

Abstract

关键词

Keywords

references

胸腺素α₁的DIC固相化学合成与鉴定

THYMOSIN α_１ SYNTHESIS WITH DIC AND ITS IDENTIFICATION