Nanoparticles，such as TiO2，are readily aggregated in aqueous medium，which always drastically deteriorates their performance.In this study，the agglomeration state of TiO2 particles in aqueous dispersion and the effects of several conventional dispersion technologies and surface grafting modification technology on the de-aggregation of TiO2 agglomeration were investigated.It was found that most of TiO2 particles in aqueous media existed as soft agglomeration.The de-aggregation effects of high-speed shear dispersion and dispersing agent on the soft agglomeration were not obvious，and the ultrasonic dispersion could only have a temporary de-aggregation effect.While the surface of TiO2 particles was grafting modified by polymer molecule via in-situ polymerization，an extensive de-aggregation effect with good efficiency and stability could be achieved.Thus the dispersion and the dispersion stability of TiO2 particle in aqueous media as well as in the fabric surface could be significantly improved.