Based on concluding the pressure drop models of single and multicyclone separator under atmosphere pressure，and on-site measurement pressure drop values，a pressure drop model has been built up to predict and calculate the pressure drops for multicyclone separators operating at different pressures and temperatures in natural gas transportation.The reliability of pressure drop models has been calibrated by experiments，the results showed that the pressure drop models could calculate exactly the pressure drop values for corresponding cyclone separators，and the differences of pressure drop values between calculated by models and measured by experiments could be ignored.Therefore，the pressure drop model of multicyclone separator at high-pressure can be used to calculate the pressure drop values for multicyclone separators under different pressures and temperatures.