Multi-objective process synthesis can be described as a multi-objective mixed-integer nonlinear programming (MOMINLP) which is difficult to solve.The process model is often based on simplified equations in the past studies

so the calculation results can not be directly used to design a complex process.A three-layer solution strategy for multi-objective synthesis based on multi-objective genetic algorithm (MOGA) in modular simulator Aspen Plus is proposed.The strategy includes simulation layer

synthesis layer and decision layer.Interface is designed to transfer data and information among three layers.The simulation mistakes are treated to avoid influencing the optimization results.A case study showed high suitability of the strategy.The results could reflect the nature of the process and could be used to design the process that meets sustainable development.