Adenine is an important chemical material widely used in the fields of medicine

organic synthesis and so onPresently

adenine is produced from the condensation of diethyl malonate with formamide

which has serious pollution problemsTo achieve the green production of adenine

noncatalyzed hydrolysis of adenosine in high temperature liquid water was carried outThe effects of initial concentration

agitating speed and temperature on adenosine hydrolysis were studied and the kinetics of adenosine hydrolysis was investigated at temperatures from 150℃ to 190℃Rate constants were evaluated with the zeroth-order reaction assumption and the activation energy was 134.1 kJ·mol-1The experimental results demonstrated that high selective preparation of adenine by non-catalyzed hydrolysis of adenosine in high temperature liquid water was possible.