The fermentation process of butanedioic acid by Actinobacillus succinogenes NJ113 with glucose as substrate was studied in batch system.Kinetic models were proposed based on the Levenspiel and Luedeking-Piret equations of cell growth
product formation and substrate consumption.With the correlated model parameters
the model could provide reasonable description for the fermentation process at various glucose concentrations.From the kinetic analysis
the microbial growth of Actinobacillus succinogenes NJ113 gradually slowed down with increasing amount of organic acids
and the growth completely ceased when the amount of organic acids exceeded 23.435 g8226;L-1 .Above this critical value
the concentration of biomass declined linearly with the rate of 0.024 h-1 and the productivity of metabolite also decreased as the fermentation proceeded.The models proposed could be used for the development and optimization of butanedioic acid production processes.