A novel technique combining photoelectronic microscopy and computer imaging tracing was used to investigate the synthesis of thioether(2-[3-methyl-4-(2

2

2-trifluoro-ethoxy)-pyridine-2-(methylsulfanyl)]-1H-benzoimidazole)

which is an intermediate for lansoprazole.Visualization in sub-microcosmic surroundings was realized to study interfacial phenomenon.The reaction kinetics study by a visualization technique was carried out in a mini-reactor

and the concentration-gray scale standard curves for thioether were obtained by analyzing the gray scales of digital images.Based on the concentration-gray scale standard curves

the reactant concentrations at different times were calculated

and the reaction kinetics curve and reaction rate equation were obtained.Also the total mass-transfer resistance from bulk phase to interface of sodium imidazole and bromopyridine was obtained.Liquid-liquid interface of synthesizing thioether was observed and its mass transfer mechanism was discussed.