GAO Yingchun, ZHANG Liang, BIAN Zhengzhong. Effects of matrix material content on soluble drug release from matrix[J]. CIESC Journal, 2005, (10): 2024-2028.
GAO Yingchun, ZHANG Liang, BIAN Zhengzhong. Effects of matrix material content on soluble drug release from matrix[J]. CIESC Journal, 2005, (10): 2024-2028.DOI:
The effects of different matrix material contents on the release of soluble drug’s mixed matrix were studied.With dissolution as guideline
and Captopril as model drug the effect of matrix material contents on the release of Captopril from hydrophilic gel matrix
wax matrix and mixed matrix were compared.The content of the matrix material had greater influence on the release of Captopril from mixed matrix than that from former single matrix. Moreover
the effect of Compritol 888 contents was more significant than that of HPMC K4M in mixed matrix.