Polysulfone hollow-fiber membrane was used and a continuous process of three-stage hollow-fiber membrane bioreactor system was designed for bio-convertion of acrylonitrile to acrylamide.On the basis of single stage membrane bioreactor

the feasibility of multiple-stage continuous process was discussed.At 20 ℃

the three-stage membrane bioreactor process steadily lasted over 80 h

the conversion of acrylonitrile was 99.9%

and the productivity was 25.3 g acrylamide8226;g cell-18226;h-1. Comparing with the original batch reaction process

the productivity was enhanced by above 40%. With the hollow-fiber membrane

immobilized cells were replaced by free cells

and steady continuous process was achieved. This process has a favorable foreground in industrial application

which leads to continuous production of acylamide.